Comparison of triblock copolymeric micelles based on α- and ε-poly(L-lysine): a Cornelian choice

Abstract Due to the lack of safe carriers for delivery small interfering RNA (siRNA), clinical applications nucleotide-based therapeutics have been limited. In this study, biodegradable amphiphilic triblock copolymers with tailored molecular weights each block composed methoxy poly(ethylene glycol) (2000 g/mol), poly( L -lysine) (1300 g/mol) and D , -lactic acid) (1800 (mPEG 45 -α-PLL 10 -PLA 25 ) were synthesized fully characterized. The peptide synthesis was carried out on a solid phase limit presence cationic charges. arrangement availability amino groups within micellar vector investigated determine colloidal stability as well predisposition these systems vectorize siRNAs in addition their already known ability improve solubility hydrophobic compounds. For purpose, copolymer containing an epsilon similarly. Accordingly, segment modifies rigidity involving complexation constraint due limited charges available surface, which can compromise efficiency into cells. addition, two vectors biocompatible different human cell lines.